Chronic pelvic pain syndrome: Highlighting medicinal plants toward biomolecules discovery for upcoming drugs formulation.

Bahare Salehi, Monica Butnariu, Mihaela Corneanu, Ioan Sarac, Sanja Vlaisavljevic, Dusanka Kitic, Amirhossein Rahavian, Amirreza Abedi, Morteza F Karkan, Indra D Bhatt, Arvind Jantwal, Javad Sharifi-Rad, Célia F Rodrigues, Miquel Martorell, Natália Martins

Journal: Phytotherapy research : PTR 2020;34(4):769-787

PMID: 31799719

Full Text on Ovid Technologies, Inc. View on PubMed

Abstract

Chronic pelvic pain syndrome (CPPS) can be triggered by a various types of gynecological, gastrointestinal, urological, and musculoskeletal disorders. Recently, the role of the central nervous system has proven to be an integral part on the development of any chronic pain syndrome, including CPPS. However, owing to the complex and heterogeneous etiology and pathophysiology of CPPS, the establishment of effective therapeutic interventions remains challenging for both physicians and patients. Nonetheless, recent studies have pointed that medicinal plants and their secondary metabolites can be effectively used in CPPS therapy, besides contributing to restore the patients' quality of life and potentiate the conventional CPPS management. In this sense, this review aims to provide a careful overview on the biomedical data for the use of medicinal plants use and their secondary metabolites on CPPS management.

Address: Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam, Iran.; Banat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timisoara, University of Timişoara, Timişoara, Romania.; Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia.; Faculty of Medicine, Department of Pharmacy, University of Niš, Bul. Zorana Djindjica 81, Serbia.; Department of Urology, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; G.B. Pant National Institute of Himalayan Environment and Sustainable Development, Kosi Katarmal, Almora, India.; Department of Pharmaceutical Sciences, Bhimtal Campus, Kumaun University, Nainital, India.; Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran.; LEPABE, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Porto, Portugal.; Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepcion, Concepcion, Chile.; Universidad de Concepción, Unidad de Desarrollo Tecnológico, Concepcion, Chile.; Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto, Portugal.; Institute for Research and Innovation in Health (i3S), University of Porto, Portugal.

DOI: 10.1002/ptr.6576

Link outs

Free resources

Medical:

https://medlineplus.gov/pelvicpain.html

Subscription / membership required

Full Text Sources:

MeSH Terms: Chronic Disease, Chronic Pain, Drug Compounding, Drug Discovery, Female, Humans, Male, Pelvic Inflammatory Disease, Pelvic Pain, Phytochemicals, Plants, Medicinal, Quality of Life, Syndrome