Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants.

Address: National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD, USA.; Bioinformatics group, Department of Computer Science, University of Freiberg, Freiberg, Germany.; Kavli Institute of Nanoscience, Department of Bionanoscience, Delft University of Technology, Delft, The Netherlands.; Max Planck Unit for the Science of Pathogens, Humboldt University, Berlin, Germany.; Arbor Biotechnologies, Cambridge, MA, USA.; DuPont Nutrition and Health, Dangé-Saint-Romain, France.; Département de biochimie, de microbiologie et de bio-informatique, Faculté des sciences et de génie, Groupe de recherche en écologie buccale, Félix d'Hérelle Reference Center for Bacterial Viruses, Faculté de médecine dentaire, Université Laval, Québec City, Québec, Canada.; Departamento de Fisiología, Genética y Microbiología, Universidad de Alicante, Alicante, Spain.; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark.; Institute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania.; Biochemistry and Molecular Biology, Genetics and Microbiology, University of Georgia, Athens, GA, USA.; Biomedical Sciences Research Complex, University of St. Andrews, St. Andrews, UK.; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Canada.; Centre for Environmental Biotechnology, School of Natural Sciences, Bangor University, Bangor, Gwynedd, UK.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Howard Hughes Medical Institute, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Archaea Centre, Department of Biology, Copenhagen University, Copenhagen, Denmark.; BIOSS Centre for Biological Signaling Studies, Cluster of Excellence, University of Freiburg, Freiburg, Germany.; Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands.; Department of Food, Bioprocessing, and Nutrition Sciences, North Carolina State University, Raleigh, NC, USA.; National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD, USA. [email protected].