Circulating irisin levels of prenatal and postnatal patients with gestational diabetes mellitus: A systematic review and meta-analysis.

Lingling Cui, Tianyi Qiao, Fan Xu, Zhonglei Li, Tingting Chen, Hongli Su, Guixia Chen, Li Zhang, Dongmei Xu, Xiaofeng Zhang

Journal: Cytokine 2021;126():154924

PMID: 31864100

Full Text on Elsevier Science View on PubMed

Abstract

AIMS

At present, there are few studies on the relationship between circulating irisin levels and gestational diabetes mellitus (GDM), and the results are inconsistent. Therefore, this study conducts a systematic review and meta-analysis to comprehensively discuss the role of irisin in the occurrence and development of GDM.

METHODS

We searched the articles on the relationship between GDM and circulating irisin levels up to September 2019, using the CNKI, WANFANG-DATA, PubMed and the Web of Science databases.

RESULTS

Twenty two articles including 3563 participants were selected in the meta-analysis. Meta-analysis found the blood irisin levels for GDM group were significantly lower than that for control group during pregnancy(SMD = -0.88, 95%CI: -1.34, -0.42, P < 0.001). However, there was no significant difference of irisin levels in the postpartum blood and cord blood between the two groups (SMD = -1.44, 95 %CI: -3.79, 0.92, P = 0.23; SMD = -0.17, 95 %CI: -0.59, 0.25, P = 0.42, respectively).

CONCLUSIONS

Compared with the control group, irisin levels in the GDM group during pregnancy are lower. However, it is no significant difference of irisin levels in the postpartum blood and cord blood. Irisin may play an important role in the occurrence and development of GDM, which needs further research to demonstrate.

Address: Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China. Electronic address: [email protected].; Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.; Department of Health, The Third Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.; Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China. Electronic address: [email protected].

DOI: 10.1016/j.cyto.2019.154924

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MeSH Terms: Diabetes, Gestational, Female, Fetal Blood, Fibronectins, Humans, Milk, Human, Postpartum Period, Pregnancy