Anti-cancer effects of Polyphyllin I: An update in 5 years.

Ye Tian, Guan-Yu Gong, Liang-Liang Ma, Zhuo-Qun Wang, Dan Song, Mei-Yun Fang

Journal: Chemico-biological interactions 2020;316():108936

PMID: 31870841

Full Text on Elsevier Science View on PubMed

Abstract

Chong-lou, the rhizome of Paris polyphylla, has been used in herbal regimes to treat parotitis, mastitis and certain malignant tumors for thousands of years in traditional medicine. Polyphyllin I (PPI) is the main bioactive component in Paris polyphylla. Recent studies of PPI in various types of cancers have shown that PPI may exert a broad spectrum of anti-tumor effects, including inducing cell cycle arrest, inducing cell apoptosis, inducing autophagy, anti-angiogenesis, sensitizing tumors to chemotherapy, and participating in the modulation of inflammatory and immune response. Along with the growing research interest in PPI as well as accumulation of experimental evidences, this review periodically summarized the recent advances in regard to PPI's anti-tumor propensities in various cancers and the underlying mechanisms for future prospective research.

Address: Department of Nephrology and Endocrinology, The Second Affiliated Hospital of Xi'an Medical University, Xi'an, 710038, China. Electronic address: [email protected].; The Institute for Translational Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.; Department of Hematology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116021, China.; Department of Oncology, Central Hospital of Zibo, Zibo, 255036, China.; Department of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116021, China.; Department of Hematology, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China. Electronic address: [email protected].

DOI: 10.1016/j.cbi.2019.108936

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MeSH Terms: Antineoplastic Agents, Phytogenic, Apoptosis, Cell Cycle Checkpoints, Diosgenin, Drug Resistance, Neoplasm, Humans, Medicine, Chinese Traditional, Neoplasms