Deoxyribonucleotide synthesis in anaerobic microorganisms: the class III ribonucleotide reductase.

Marc Fontecave, Etienne Mulliez, Derek T Logan

Journal: Progress in nucleic acid research and molecular biology 2002;72():95-127

PMID: 12206460

Abstract

For growth under oxygen-free atmosphere, some strict or facultative anaerobes depend on a class III ribonucleotide reductase for the synthesis of deoxyribonucleotides, the DNA precursors. Prototypes for this class of enzymes are ribonucleotide reductases from Escherichia coli and bacteriophage T4. This review article describes their structural and mechanistic properties as well as their complex allosteric regulation. Their evolutionnary relationship to class I and class II ribonucleotide reductases is also discussed.

Address: Laboratoire de Chimie et Biochimie des Centres Rédox Biologiques, UMR CNRS/CEA/Université Joseph DRDC-CB, CEA Grenoble, France.

DOI: 10.1016/s0079-6603(02)72068-0

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https://biocyc.org/gene?orgid=ECOLI&id=EG11417

MeSH Terms: Amino Acid Sequence, Anaerobiosis, Bacteria, Anaerobic, Bacterial Proteins, DNA, Deoxyribonucleotides, Escherichia coli Proteins, Gene Expression Regulation, Molecular Sequence Data, RNA, Ribonucleotide Reductases, Viral Proteins