Viral Manipulations of the Cullin-RING Ubiquitin Ligases.

Ying Liu, Xu Tan

Journal: Advances in experimental medicine and biology 2020;1217():99-110

PMID: 31898224

Abstract

Cullin-RING ubiquitin ligases (CRLs) are efficient and diverse toolsets of the cells to regulate almost every biological process. However, these characteristics have also been usurped by many viruses to optimize for their replication. CRLs are often at the forefront of the arms races in the coevolution of viruses and hosts. Here we review the modes of actions and functional consequences of viral manipulations of host cell CRLs. We also discuss the therapeutic applications to target these viral manipulations for treating viral infections.

Address: MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structures, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.; MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structures, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China. [email protected].

DOI: 10.1007/978-981-15-1025-0_7

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https://dx.doi.org/10.1007/978-981-15-1025-0_7

MeSH Terms: Biological Evolution, Cullin Proteins, Host-Pathogen Interactions, Humans, Virus Diseases, Virus Replication, Viruses