Yeast systems biology in understanding principles of physiology underlying complex human diseases.

Rosemary Yu, Jens Nielsen

Journal: Current opinion in biotechnology 2020;63():63-69

PMID: 31901548

Full Text on Elsevier Science View on PubMed

Abstract

Complex human diseases commonly arise from deregulation of cell growth, metabolism, and/or gene expression. Yeast is a eukaryal model organism that is widely used to study these processes. Yeast systems biology benefits from the ability to exert fine experimental control over the cell growth rate and nutrient composition, which allows orthogonal experimental design and generation of multi-omics data at high resolution. This has led to several insights on the principles of cellular physiology, including many cellular processes associated with complex human diseases. Here we review these biological insights together with experimental and modeling approaches developed in yeast to study systems biology. The role of yeast systems biology to further advance systems and personalized therapies for complex diseases is discussed.

Address: Department of Biology and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden; Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden.; Department of Biology and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden; Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark; BioInnovation Institute, Ole Måløes Vej 3, DK-2200 Copenhagen N, Denmark. Electronic address: [email protected].

DOI: 10.1016/j.copbio.2019.11.021

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MeSH Terms: Humans, Saccharomyces cerevisiae, Systems Biology