Pathogenesis of Diverticulosis and Diverticular Disease.

Juozas Kupcinskas, Lisa L Strate, Gabrio Bassotti, Gabriele Torti, László Herszènyi, Peter Malfertheiner, Claudio Cassieri, Marjorie Md Walker, Antonio Tursi

Journal: Journal of gastrointestinal and liver diseases : JGLD 2020;28(suppl. 4):7-10

PMID: 31930230

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Abstract

In this session different problems regarding the pathogenesis of diverticular disease were considered, including "Genetics", "Neuromuscular function abnormalities", "Patterns of mucosa inflammation", and "Impact of lifestyle". The patients affected by diverticular disease have clear genetic pattern, that might predispose to the occurrence of the disease as well as to its complications. Neuromuscular abnormalities may be recognized already at the stage of diverticulosis, and inflammation may explain symptoms occurrence in symptomatic uncomplicated diverticular disease (SUDD) or symptoms persistence after an episode of acute diverticulitis. Finally, lifestyle might also have an impact on symptoms' occurrence. Specifically smoking, but also obesity seem to play an important role, while the role of low-fiber diet and constipation is now under debate.

Address: Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania. . [email protected].; Division of Gastroenterology, Department of Medicine, Harborview Medical Center, University of Washington Medical School, Seattle, Washington, USA. [email protected].; Department of Clinical and Experimental Medicine, Gastroenterology and Hepatology Section, "Santa Maria della Misericordia" Hospital, University of Perugia, San Sisto (PG), Italy. [email protected].; Department of Clinical and Experimental Medicine, Gastroenterology and Hepatology Section, "Santa Maria della Misericordia" Hospital, University of Perugia, San Sisto (PG), Italy. [email protected].; 2nd Department of Medicine, Semmelweis University, H-1088 Budapest, Hungary. [email protected].; Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany. [email protected].; Division of Internal Medicine and Gastroenterology, "Cristo Re" Hospital, Rome, Italy. [email protected].; University of Newcastle, Faculty of Health and Medicine, School of Medicine and Public Health, Australian Gastrointestinal Research Alliance, Callaghan NSW 2308, Australia. [email protected].; Territorial Gastroenterology Service, ASL BAT, Andria, Italy. [email protected].

DOI: 10.15403/jgld-551

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https://doi.org/10.15403/jgld-551

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https://medlineplus.gov/diverticulosisanddiverticu...

MeSH Terms: Colon, Diverticular Diseases, Diverticulum, Gastrointestinal Motility, Genetic Predisposition to Disease, Humans, Life Style, Obesity, Sensation, Sensation Disorders, Smoking