Polyarteritis nodosa isolated to muscles-A case series with a review of the literature.

Luckshman R Ganeshanandan, Anna M Brusch, Jason M Dyke, Andrew P C McLean-Tooke

Journal: Seminars in arthritis and rheumatism 2021;50(3):503-508

PMID: 31959304

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Abstract

Muscular polyarteritis nodosa where disease is isolated to skeletal muscle is a rare and often poorly recognised clinical entity. Patients typically present with fever and severe muscle pain limiting ability to ambulate without rise in creatine kinase. Often there is a significant delay between presentation and diagnosis, which requires histological confirmation. Musculoskeletal MRI is a sensitive investigation that can lead to timely biopsy and improve diagnostic yield. Early diagnosis of this condition is essential as patients typically respond favourably to corticosteroid treatment. Here we report 4 cases of muscular polyarteritis nodosa and review the reported literature.

Address: Department of Clinical Immunology, PathWest Laboratory Medicine WA, Queen Elizabeth II Medical Centre, Perth, Western Australia, Australia; Department of Clinical Immunology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. Electronic address: [email protected].; Department of Clinical Immunology, PathWest Laboratory Medicine WA, Queen Elizabeth II Medical Centre, Perth, Western Australia, Australia; Department of Clinical Immunology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.; Department of Neuropathology, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Western Australia, Australia.

DOI: 10.1016/j.semarthrit.2019.12.002

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MeSH Terms: Adult, Aged, Anti-Inflammatory Agents, Antirheumatic Agents, Female, Humans, Immunoglobulins, Intravenous, Immunologic Factors, Lower Extremity, Male, Methotrexate, Middle Aged, Muscle, Skeletal, Myalgia, Polyarteritis Nodosa