Curcumin for the Management of Periodontal Diseases: A Review.

Fatemeh Forouzanfar, Ali Forouzanfar, Thozhukat Sathyapalan, Hossein M Orafai, Amirhossein Sahebkar

Journal: Current pharmaceutical design 2021;26(34):4277-4284

PMID: 32400326

Abstract

Periodontal disease is one of the most common causes of tooth loss among adults. Research shows that inflammation is one of the crucial components in the initiation and progression of periodontitis. Various herbal medicines have recently been receiving attention for the management of periodontitis owing to their general safety and efficacy. Curcumin, a bioactive polyphenol extracted from Curcuma longa, has been shown to possess antioxidant, antimicrobial, anti-inflammatory and analgesic properties. Several studies have assessed the efficacy of curcumin against periodontal diseases. These studies have shown equivalent or even higher efficacy of curcumin compared to the commonly used medications for the management of periodontitis such as chlorhexidine. Herein, we review the experimental and clinical findings on the anti-periodontitis effects of curcumin and the pharmacological mechanisms underlying these effects.

Address: Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Dental Research Center, School of Dentistry, Mashhad University of Medical Sciences Mashhad, Iran.; Department of Periodontology, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.; Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, United Kingdom.; Department of Pharmaceutics, Faculty of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq.; Halal Research Center of IRI, FDA, Tehran, Iran.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

DOI: 10.2174/1381612826666200513112607

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MeSH Terms: Adult, Anti-Inflammatory Agents, Chlorhexidine, Curcumin, Humans, Inflammation, Periodontal Diseases, Periodontitis