CYP26B1 and its implications in lymphangiogenesis: Literature review and study of rare variants in two families.

J Krajcovic, M Bertelli, S H Basha, M Dundar, L Gagliardi, V Velluti, G Matera, B Aquilanti, G A D Miggiano, M Ricci, M Baglivo, D Kurti, S Kenanoglu, D Veselenyiova, R Compagna, B Amato, R Serrani

Journal: Lymphology 2021;53(1):20-28

PMID: 32521127

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Abstract

CYP26B1 is a member of the cytochrome P450 family and is responsible for the break-down of retinoic acid for which appropriate levels are important for normal development of the cardiovascular and lymphatic systems. In a cohort of 235 patients with lymphatic malformations, we performed genetic testing for the CYP26B1 gene. These probands had previously tested negative for known lymphedema genes. We identified two heterozygous missense CY-P26B1 variants in two patients. Our bioinformatic study suggested that alterations caused by these variants have no major effect on the overall stability of CYP26B1 protein structure. Balanced levels of retinoic acid maintained by CYP26B1 are crucial for the lymphatic system. We identified that CYP26B1 could be involved in predisposition for lymphedema. We propose that CYP26B1 be further explored as a new candidate gene for genetic testing of lymphedema patients.

Address: Division of Rehabilitation Medicine, Azienda Ospedaliero-Universitaria, Ospedali Riuniti di Ancona, Italy.; Department of General and Geriatric Surgery, University of Naples "Federico II", Naples, Italy.; Department of Public Health (RC), University of Naples Federico II, Naples, Italy.; Department of Biology, Faculty of Natural Sciences, University of Ss. Cyril and Methodius In Trnava, Trnava, Slovakia.; MAGI Euregio, Bolzano, BZ (headquarters); San Felice del Benaco (branch), Italy.; Department of Medical Genetics, Faculty of Medicine, Erciyes University, Kayseri, Turkey.; Research Center in Human Nutrition (GADM), Sacro Cuore Catholic University, Rome, Italy.; UOC Clinical Nutrition, Department of Medical Genetics, Faculty of Medicine, Erciyes University, Kayseri, Turkey.; Policlinico Universitario Foundation A. Gemelli IRCCS, Rome, Italy.; Innovative Informatica Technologies (SHB), Hyderabad, India.; MAGI-Balkan, Tirana, Albania.; EBTNA-Lab, Rovereto, TN, (headquarters), San Felice del Benaco, Italy.; MAGI's Lab, Rovereto, TN, (headquarters); San Felice del Benaco, Italy.

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Medical:

https://medlineplus.gov/lymphedema.html

MeSH Terms: Female, Humans, Lymphangiogenesis, Lymphedema, Middle Aged, Mutation, Missense, Prognosis, Protein Conformation, Retinoic Acid 4-Hydroxylase