Advances and challenges in the prevention and treatment of COVID-19.

Yan-Jie Han, Zhi-Guang Ren, Xin-Xin Li, Ji-Liang Yan, Chun-Yan Ma, Dong-Dong Wu, Xin-Ying Ji

Journal: International journal of medical sciences 2020;17(12):1803-1810

PMID: 32714083

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Abstract

Since the end of 2019, a new type of coronavirus pneumonia (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been spreading rapidly throughout the world. Previously, there were two outbreaks of severe coronavirus caused by different coronaviruses worldwide, namely Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). This article introduced the origin, virological characteristics and epidemiological overview of SARS-CoV-2, reviewed the currently known drugs that may prevent and treat coronavirus, explained the characteristics of the new coronavirus and provided novel information for the prevention and treatment of COVID-19.

Address: Kaifeng Key Laboratory for Infectious Diseases and Biosafety, School of Basic Medical Science, Henan University, Kaifeng, Henan 475004, China.; Henan International Joint Laboratory of Nuclear Protein Regulation, School of Basic Medical Science, Henan University, Kaifeng, Henan 475004, China.; Clinical Laboratory and Functional Laboratory, Kaifeng Central Hospital, Kaifeng, Henan 475000, China.; School of Stomatology, Henan University, Kaifeng, Henan 475004, China.

DOI: 10.7150/ijms.47836

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MeSH Terms: Amides, Antibodies, Monoclonal, Antiviral Agents, Betacoronavirus, COVID-19, Chloroquine, Chlorpromazine, Coronavirus, Coronavirus Infections, Cyclophilins, Drug Development, Drug Repositioning, Drugs, Chinese Herbal, Endocytosis, Humans, Immune Sera, Interferon Inducers, Nucleic Acid Synthesis Inhibitors, Pandemics, Pneumonia, Viral, Pyrazines, Resveratrol, SARS-CoV-2, Viral Vaccines, COVID-19 Drug Treatment