A Perspective on Emerging Therapeutic Interventions for COVID-19.

Muhammad Torequl Islam, Md Nasiruddin, Ishaq N Khan, Siddhartha Kumar Mishra, Md Kudrat-E-Zahan, Thoufiqul Alam Riaz, Eunus S Ali, M Safiur Rahman, Mohammad S Mubarak, Miquel Martorell, William C Cho, Daniela Calina, Anca Oana Docea, Javad Sharifi-Rad

Journal: Frontiers in public health 2021;8():281

PMID: 32733837

Abstract

Coronaviruses are enveloped positive-sense RNA viruses with an unusual large RNA genome and a unique replication mechanism, which are characterized by club-like spikes that protrude from their surface. An outbreak of a novel coronavirus 2019 infection has posed significant threat to the health and economies in the whole world. This article reviewed the viral replication, pathogenicity, prevention and treatment strategies. With a lack of approved treatment options for this virus, alternative approaches to control the spread of disease is in urgent need. This article also covers some management strategies which may be applied to this virus outbreak. Ongoing clinical studies related to possible treatments for COVID-19, potential vaccines, and alternative medication such as natural compounds are also discussed.

Copyright © 2020 Torequl Islam, Nasiruddin, Khan, Mishra, Kudrat-E-Zahan, Alam Riaz, Ali, Rahman, Mubarak, Martorell, Cho, Calina, Docea and Sharifi-Rad.

Address: Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.; Department of Chemistry, Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.; Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan.; Cancer Biology Laboratory, Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Central University, Sagar, India.; Department of Chemistry, Rajshahi University, Rajshahi, Bangladesh.; Department of Pharmacology, School of Medicine, Institute of New Drug Development, Jeonbuk National University, Jeonju, South Korea.; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.; Environmental and Atmospheric Chemistry Laboratory, Bangladesh Atomic Energy Commission, Dhaka, Bangladesh.; Department of Chemistry, The University of Jordan, Amman, Jordan.; Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepcion, Concepcion, Chile.; Centre for Healthy Living, University of Concepción, Concepción, Chile.; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China.; Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania.; Department of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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