Serum very long-chain fatty acids (VLCFA) levels as predictive biomarkers of diseases severity and probability of survival in peroxisomal disorders.

Teresa Joanna Stradomska, Małgorzata Syczewska, Ewa Jamroz, Agata Pleskaczyńska, Piotr Kruczek, Elżbieta Ciara, Anna Tylki-Szymanska

Journal: PloS one 2020;15(9):e0238796

PMID: 32946460

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Abstract

VLCFA levels correlate with the severity of the clinical course of ZS, DBP and mild ZSD. The best predictive value for estimating the projected disease severity and survival time is a concentration of C26:0.

Address: Department of Biochemistry, Radioimmunology & Experimental Medicine, Children's Memorial Health Institute, Warsaw, Poland.; Department of Pediatrics Rehabilitation, Children's Memorial Health Institute, Warsaw, Poland.; Department of Pediatric and Neurology of Developmental Age, Clinical Hospital No. 6 of Medical University of Silesia, Katowice, Poland.; Department of Neonatology, Pathology and Neonatal Intensive Care Unit, Children's Memorial Health Institute, Warsaw, Poland.; Department of Neonatal Pathology and Intensive Care Unit, University Children's Hospital of Cracow, Cracow, Poland.; Department of Medical Genetics, Children's Memorial Health Institute, Warsaw, Poland.; Department of Pediatrics, Nutrition and Metabolic Disease, Children's Memorial Health Institute, Warsaw, Poland.

DOI: 10.1371/journal.pone.0238796

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MeSH Terms: Adolescent, Biomarkers, Child, Child, Preschool, Fatty Acids, Female, Humans, Infant, Infant, Newborn, Male, Peroxisomal Disorders, Prognosis, Retrospective Studies, Severity of Illness Index, Survival Analysis, Young Adult, Zellweger Syndrome