Iron Serum Markers Profile in Frontotemporal Lobar Degeneration.

Anastasia De Luca, Silvia Fostinelli, Clarissa Ferrari, Giuliano Binetti, Luisa Benussi, Barbara Borroni, Luisa Rossi, Mauro Rongioletti, Roberta Ghidoni, Rosanna Squitti

Journal: Journal of Alzheimer's disease : JAD 2021;78(4):1373-1380

PMID: 33185611

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Abstract

Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative syndrome. Defects of copper (Cu) and iron (Fe) homeostasis are involved in the development of several neurodegenerative diseases and their homeostasis is interconnected by the Cu-protein ceruloplasmin (Cp), responsible for Fe oxidative state. In this study we assessed Fe, transferrin (Trf), ferritin, Cp specific activity (eCp/iCp), Cp/Trf ratio, and Trf saturation in 60 FTLD patients and 43 healthy controls, and discussed the results in relation to Cu homeostasis. The significant decrease of the eCp/iCp in the FTLD patients supports the involvement of Fe imbalance in the onset and progression of FTLD.

Address: Department of Biology, University of Rome Tor Vergata, Rome, Italy.; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.; Statistics Service, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.; MAC Memory Clinic and Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.; Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.; Department of Laboratory Medicine, Research and Development Division, San Giovanni Calibita Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy.

DOI: 10.3233/JAD-201047

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MeSH Terms: Aged, Aphasia, Primary Progressive, Case-Control Studies, Ceruloplasmin, Female, Ferritins, Frontotemporal Dementia, Frontotemporal Lobar Degeneration, Humans, Iron, Male, Middle Aged, Transferrin