Metabolic Regulation of Immune Responses to : A Spotlight on L-Arginine and L-Tryptophan Metabolism.

Rebecca R Crowther, Joseph E Qualls

Journal: Frontiers in immunology 2021;11():628432

PMID: 33633745

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Abstract

(), the causative agent of tuberculosis (TB), is a leading cause of death worldwide. Despite decades of research, there is still much to be uncovered regarding the immune response to infection. Here, we summarize the current knowledge on anti- immunity, with a spotlight on immune cell amino acid metabolism. Specifically, we discuss L-arginine and L-tryptophan, focusing on their requirements, regulatory roles, and potential use as adjunctive therapy in TB patients. By continuing to uncover the immune cell contribution during infection and how amino acid utilization regulates their functions, it is anticipated that novel host-directed therapies may be developed and/or refined, helping to eradicate TB.

Address: Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, United States.; Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH, United States.

DOI: 10.3389/fimmu.2020.628432

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https://medlineplus.gov/tuberculosis.html

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https://scite.ai/reports/33633745

MeSH Terms: Arginine, Humans, Mycobacterium tuberculosis, Tryptophan, Tuberculosis