Parenteral systems for statin delivery: a review.

Thomas P Johnston, Shahla Korani, Samira Bahrami, Mitra Korani, Maciej Banach, Amirhossein Sahebkar

Journal: Lipids in health and disease 2020;18(1):193

PMID: 31690335

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Abstract

The oral route of drug administration is the most common and convenient route for dosing statin drugs, and, in fact, most medications, because of ease of drug delivery, patient compliance, and cost-effectiveness. However, the oral administration of statin drugs has disadvantages such as hepatic first-pass metabolism and degradation within the gastrointestinal tract that limit their overall bioavailability. This review introduces several diverse non-oral delivery methods for the administration of statins. These alternative delivery systems and routes of administration are varied and are capable of improving the bioavailability and therapeutic efficacy of statin drugs.

Address: Research center of oils and fats, Kermanshah University of Medical Sciences, Kermanshah, Iran.; Biotechnology Department, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Nanotechnology Research Center, Buali (Avicenna) Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, Lodz, Poland.; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland.; Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, Missouri, USA.; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. [email protected].; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran. [email protected].; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. [email protected].; Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, P.O. Box: 91779-48564, Mashhad, Iran. [email protected].

DOI: 10.1186/s12944-019-1139-8

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https://medlineplus.gov/cholesterolmedicines.html

MeSH Terms: Administration, Buccal, Administration, Cutaneous, Administration, Intravenous, Drug Delivery Systems, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors