The Effect of Curcumin on the Differentiation of Mesenchymal Stem Cells into Mesodermal Lineage.

Armita Mahdavi Gorabi, Nasim Kiaie, Saeideh Hajighasemi, Tannaz Jamialahmadi, Muhammed Majeed, Amirhossein Sahebkar

Journal: Molecules (Basel, Switzerland) 2020;24(22):4029

PMID: 31703322

Abstract

Curcumin has been placed at the forefront of the researcher's attention due to its pleiotropic pharmacological effects and health benefits. A considerable volume of articles has pointed out curcumin's effects on the fate of stem cell differentiation. In this review, a descriptive mechanism of how curcumin affects the outcome of the differentiation of mesenchymal stem cells (MSCs) into the mesodermal lineage-i.e., adipocyte, osteocyte, and chondrocyte differentiation-is compiled from the literature. The sections include the mechanism of inhibition or induction of MSCs differentiation to each lineage, their governing molecular mechanisms, and their signal transduction pathways. The effect of different curcumin doses and its structural modifications on the MSCs differentiation is also discussed.

Address: Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran 1411713138, Iran.; Department of Medical Biotechnology, Faculty of Paramedicine, Qazvin University of Medical Sciences, Qazvin 15315-34199, Iran.; Halal Research Center of IRI, FDA, Tehran, Iran.; Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Sabinsa Corporation, East Windsor, NJ 08520, USA.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; University of Western Australia, Perth 6009, Australia.; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

DOI: 10.3390/molecules24224029

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MeSH Terms: Cell Differentiation, Cell Lineage, Curcumin, Dose-Response Relationship, Drug, Humans, Mesenchymal Stem Cells, Mesoderm, Signal Transduction