Micronutrient Depletion in Heart Failure: Common, Clinically Relevant and Treatable.

Natasa Cvetinovic, Goran Loncar, Andjelka M Isakovic, Stephan von Haehling, Wolfram Doehner, Mitja Lainscak, Jerneja Farkas

Journal: International journal of molecular sciences 2020;20(22):5627

PMID: 31717934

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Abstract

Heart failure (HF) is a chronic condition with many imbalances, including nutritional issues. Next to sarcopenia and cachexia which are clinically evident, micronutrient deficiency is also present in HF. It is involved in HF pathophysiology and has prognostic implications. In general, most widely known micronutrients are depleted in HF, which is associated with symptoms and adverse outcomes. Nutritional intake is important but is not the only factor reducing the micronutrient availability for bodily processes, because absorption, distribution, and patient comorbidity may play a major role. In this context, interventional studies with parenteral micronutrient supplementation provide evidence that normalization of micronutrients is associated with improvement in physical performance and quality of life. Outcome studies are underway and should be reported in the following years.

Address: Department of Cardiology, University Clinical Hospital Center "Dr. Dragisa Misovic-Dedinje", 11000 Belgrade, Serbia.; Institute for Cardiovascular Diseases Dedinje, 11000 Belgrade, Serbia.; School of Medicine, University of Belgrade, 11000 Belgrade, Serbia.; Department of Cardiology and Pneumology, University of Goettingen Medical Center, DE-37075 Goettingen, Germany.; German Center for Cardiovascular Research (DZHK), partner site Goettingen, DE-37099 Goettingen, Germany.; Berlin Institute of Health Center for Regenerative Therapies (BCRT) and Department of Cardiology (Virchow Klinikum), German Centre for Cardiovascular Research (DZHK) partner site Berlin, Charité Universitätsmedizin Berlin, DE-13353 Berlin, Germany.; Division of Cardiology, General Hospital Murska Sobota, SI-9000 Murska Sobota, Slovenia.; Faculty of Medicine, University of Ljubljana, SI-1000 Ljubljana, Slovenia.; Research Unit, General Hospital Murska Sobota, SI-9000 Murska Sobota, Slovenia.; National Institute of Public Health, SI-1000 Ljubljana, Slovenia.

DOI: 10.3390/ijms20225627

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Full Text Sources:

Medical:

https://medlineplus.gov/heartfailure.html

Miscellaneous:

https://assays.cancer.gov/non-CPTAC-2658

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-GZMA-1

MeSH Terms: Avitaminosis, Heart Failure, Humans, Trace Elements, Vitamins