Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature.

Bahare Salehi, Shashi Upadhyay, Ilkay Erdogan Orhan, Arun Kumar Jugran, Sumali L D Jayaweera, Daniel A Dias, Farukh Sharopov, Yasaman Taheri, Natália Martins, Navid Baghalpour, William C Cho, Javad Sharifi-Rad

Journal: Biomolecules 2020;9(11):738

PMID: 31739596

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Abstract

α- and β-pinene are well-known representatives of the monoterpenes group, and are found in many plants' essential oils. A wide range of pharmacological activities have been reported, including antibiotic resistance modulation, anticoagulant, antitumor, antimicrobial, antimalarial, antioxidant, anti-inflammatory, anti- and analgesic effects. This article aims to summarize the most prominent effects of α- and β-pinene, namely their cytogenetic, gastroprotective, anxiolytic, cytoprotective, anticonvulsant, and neuroprotective effects, as well as their effects against HO-stimulated oxidative stress, pancreatitis, stress-stimulated hyperthermia, and pulpal pain. Finally, we will also discuss the bioavailability, administration, as well as their biological activity and clinical applications.

Address: Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran.; G. B. Pant National Institute of Himalayan Environment and Sustainable Development, Kosi- Katarmal, Almora-263643, Uttarakhand, India.; Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey.; G. B. Pant National Institute of Himalayan Environment and Sustainable Development, Garhwal Regional Centre, Srinagar-246174, Uttarakhand, India.; School of Health and Biomedical Sciences, Discipline of Laboratory Medicine, RMIT University, Bundoora PO Box 71, VIC 3083, Australia.; Department of Pharmaceutical Technology, Avicenna Tajik State Medical University, Rudaki 139, Dushanbe 734003, Tajikistan.; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, Iran.; Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.; Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal.; Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong, China.; Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615-585, Iran.

DOI: 10.3390/biom9110738

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MeSH Terms: Bicyclic Monoterpenes