Ferroptosis and kidney diseases.

Shumei Tang, Xiangcheng Xiao

Journal: International urology and nephrology 2020;52(3):497-503

PMID: 31768804

Abstract

Ferroptosis is a form of iron-dependent, non-apoptotic regulated cell death, which is characterized by the accumulation of lipid hydroperoxides to lethal levels. Ferroptosis recently has been shown to have implications in diverse kidney diseases, such as acute kidney injury, polycystic kidney disease and renal cell carcinoma. This review summarizes current research on ferroptosis, its underlying mechanisms and its role in the progression of different kidney diseases to provide more information regarding treatment and prevention of these destructive diseases.

Address: Department of Nephrology, Central South University, Xiangya Hospital, Xiangya Road No 87, Changsha, Hunan, 41008, China.; Department of Nephrology, Central South University, Xiangya Hospital, Xiangya Road No 87, Changsha, Hunan, 41008, China. [email protected].

DOI: 10.1007/s11255-019-02335-7

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https://doi.org/10.1007/s11255-019-02335-7

MeSH Terms: Disease Progression, Ferroptosis, Humans, Kidney Diseases, Regulated Cell Death