Skin blood flow response to topically applied methyl nicotinate: Possible mechanisms.

Sherif Elawa, Robin Mirdell, Simon Farnebo, Erik Tesselaar

Journal: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2021;26(3):343-348

PMID: 31777124

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Abstract

BACKGROUND

Methyl nicotinate (MN) induces a local cutaneous erythema in the skin and may be valuable as a local provocation in the assessment of microcirculation and skin viability. The mechanisms through which MN mediates its vascular effect are not fully known. The aim of this study was to characterize the vasodilatory effects of topically applied MN and to study the involvement of nitric oxide (NO), local sensory nerves, and prostaglandin-mediated pathways.

METHODS

MN was applied on the skin of healthy subjects in which NO-mediated (L-NMMA), nerve-mediated (lidocaine/prilocaine), and cyclooxygenase-mediated (NSAID) pathways were selectively inhibited. Microvascular responses in the skin were measured using laser speckle contrast imaging (LSCI).

RESULTS

NSAID reduced the MN-induced perfusion increase with 82% (P < .01), whereas lidocaine/prilocaine reduced it with 32% (P < .01). L-NMMA did not affect the microvascular response to MN.

CONCLUSION

The prostaglandin pathway and local sensory nerves are involved in the vasodilatory actions of MN in the skin.

Address: Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.; Department of Plastic Surgery, Hand Surgery, and Burns, Linköping University, Linköping, Sweden.; Department of Medical Radiation Physics, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.

DOI: 10.1111/srt.12807

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MeSH Terms: Administration, Topical, Adult, Anti-Inflammatory Agents, Non-Steroidal, Case-Control Studies, Female, Humans, Iontophoresis, Male, Microcirculation, Neurons, Afferent, Nicotinic Acids, Nitric Oxide Synthase, Prostaglandins, Regional Blood Flow, Skin, Tissue Survival, Vasodilation, Vitamin B Complex