Functional changes of biomolecules and organocatalysts as a probe for pressure effects in solution.

Thomas Weinbender, Martin Hofmann, Oliver Reiser

Journal: Biophysical chemistry 2020;257():106280

PMID: 31877450

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Abstract

High pressure acts as a mild and non-destructive activation mode for chemical reactions. However, in the context of organo-/biocatalysis, high pressure activation, has not been investigated systematically, although there are significant benefits such as rate acceleration, increased selectivity and the possibility of suppressing side product formation. The influence of hydrostatic pressure in solution on the catalytic performance of enzymes and small molecule organocatalysts such as amino acids, peptides, amines, cinchona alkaloids and thioureas is evaluated in this review, taking reactivity and selectivity as a probe to identify pressure effects on biomolecules.

Address: Institute of Organic Chemistry, University Regensburg Universitätsstr, 31, 93053 Regensburg, Germany.; Institute of Organic Chemistry, University Regensburg Universitätsstr, 31, 93053 Regensburg, Germany. Electronic address: [email protected].

DOI: 10.1016/j.bpc.2019.106280

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MeSH Terms: Amino Acids, Catalysis, Cinchona Alkaloids, Cycloaddition Reaction, Enzymes, Peptides, Pressure, Solutions, Thiourea