Synthetic Strategies for (-)-Cannabidiol and Its Structural Analogs.

Byunghyuck Jung, Jungkyu K Lee, Jungnam Kim, Eunhye K Kang, Sang Yeong Han, Hee-Yoon Lee, Insung S Choi

Journal: Chemistry, an Asian journal 2019;14(21):3749-3762

PMID: 31529613

Abstract

(-)-Cannabidiol ((-)-CBD), a non-psychoactive phytocannabinoid from Cannabis, and its structural analogs have received growing attention in recent years because of their potential therapeutic benefits, including neuroprotective, anti-epileptic, anti-inflammatory, anxiolytic, and anti-cancer properties. (-)-CBD and its analogs have been obtained mainly based on extraction from the natural source; however, the conventional extraction-based methods have some drawbacks, such as poor quality control along with purification difficulty. Chemical-synthetic strategies for (-)-CBD could tackle these issues, and, additionally, generate novel (-)-CBD analogs that exhibit advanced biological activities. This review concisely summarizes the historic and recent milestones in the synthetic strategies for (-)-CBD and its analogs.

Address: School of Undergraduate Studies, DGIST, Daegu, 42988, Korea.; Department of Chemistry, Green-Nano Materials Research Center, Kyungpook National University, Daegu, 41566, Korea.; Department of Chemistry, KAIST, Daejeon, 34141, Korea.

DOI: 10.1002/asia.201901179

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https://doi.org/10.1002/asia.201901179

MeSH Terms: Cannabidiol, Cannabis, Molecular Structure