New Lignans from roots of Kadsura coccinea.

Yupei Yang, Yongbei Liu, Muhammad Daniyal, Huanghe Yu, Qingling Xie, Bin Li, Yuqing Jian, Rongyong Man, Sanhu Wang, Xiaoling Zhou, Bin Liu, Wei Wang

Journal: Fitoterapia 2019;139():104368

PMID: 31629046

Full Text on Elsevier Science View on PubMed

Abstract

Four new dibenzocyclooctadiene lignans, named heilaohusus A-D (1-4), one new arylnaphthalene lignan named heilaohusu E (5), and seven known analogues (6-12) were isolated from the roots of Kadsura coccinea. Their structures and configurations were elucidated by a combination of HR-ESI-MS, H NMR, C NMR, HSQC, HMBC, NOESY and CD spectra. Among the known compounds, compounds 6 and 8-12 were isolated from this plant for the first time. All of compounds were evaluated for their cytotoxicity activities, compounds 3, 6 and 7 showed weak cytotoxicity against four human cancer cell lines (HepG-2, HCT-116, BGC-823 and Hela) with IC values range from 13.04 to 21.93 μM. Compounds 1 and 7 demonstrated potential anti-RA (rheumatoid arthritis) activity against RA-FLS cell line with IC values of 14.57 and 11.70 μM, respectively.

Address: TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, People's Republic of China.; TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, People's Republic of China. Electronic address: [email protected].; Clinic Experimental Research Center, the first people's hospital of Huaihua, Huihua 418000, People's Republic of China.; Department of Gastroenterology, Liuzhou Traditional Chinese Medical Hospital, Liuzhou 545001, People's Republic of China.; Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha 410125, People's Republic of China.; TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, People's Republic of China. Electronic address: [email protected].

DOI: 10.1016/j.fitote.2019.104368

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MeSH Terms: Antineoplastic Agents, Phytogenic, Antirheumatic Agents, Cell Line, Tumor, China, Cyclooctanes, Humans, Kadsura, Lignans, Molecular Structure, Phytochemicals, Plant Roots