Fungal keratitis: Pathogenesis, diagnosis and prevention.

Lingzhi Niu, Xin Liu, Zhiming Ma, Yuan Yin, Lixia Sun, Longfei Yang, Yajuan Zheng

Journal: Microbial pathogenesis 2020;138():103802

PMID: 31626916

Full Text on Elsevier Science View on PubMed

Abstract

As a kind of serious, potentially sight-threatening corneal infections with poor prognosis, fungal keratitis can bring a heavy economic burden to patients and seriously affect the quality of life, especially those in developing countries where fungal keratitis is more prevalent. Typical clinical features include immune rings, satellite lesions, pseudopods, hypha moss, hypopyon and endothelial plaques. The ideal therapeutic effects could not be achieved by current treatments for many reasons. Therefore, under the current status, understanding the pathogenesis, early diagnosis and prevention strategies might be of great importance. Here, in this review, we discuss the recent progresses that may advance our understanding of pathogenesis, early diagnosis and prevention of fungal keratitis.

Address: Eye Center, The Second Hospital of Jilin University, Changchun 130041, China.; Department of Gastrointestinal Nutrition and Hernia Surgery, The Second Hospital of Jilin University, Changchun 130041, China.; Department of Ophthalmology, Yanbian University Affiliated Hospital, Yanbian University, Yanji, 133000, China.; Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun 130041, China. Electronic address: [email protected].; Eye Center, The Second Hospital of Jilin University, Changchun 130041, China. Electronic address: [email protected].

DOI: 10.1016/j.micpath.2019.103802

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MeSH Terms: Biomarkers, Disease Management, Disease Susceptibility, Eye Infections, Fungal, Host-Pathogen Interactions, Humans, Keratitis, Microscopy, Confocal, Molecular Diagnostic Techniques, Risk Factors, Tomography