Microbial production of vitamin K2: current status and future prospects.

Lujing Ren, Cheng Peng, Xuechao Hu, Yiwen Han, He Huang

Journal: Biotechnology advances 2020;39():107453

PMID: 31629792

Full Text on Elsevier Science View on PubMed

Abstract

Vitamin K2, also called menaquinone, is an essential lipid-soluble vitamin that plays a critical role in blood clotting and prevention of osteoporosis. It has become a focus of research in recent years and has been widely used in the food and pharmaceutical industries. This review will briefly introduce the functions and applications of vitamin K2 first, after which the biosynthesis pathways and enzymes will be analyzed in-depth to highlight the bottlenecks facing the microbial vitamin K2 production on the industrial scale. Then, various strategies, including strain mutagenesis and genetic modification, different cultivation modes, fermentation and separation processes, will be summarized and discussed. The future prospects and perspectives of microbial menaquinone production will also be discussed finally.

Address: College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, No. 30 South Puzhu Road, Nanjing 211816, People's Republic of China.; School of Pharmaceutical Sciences, Nanjing Tech University, No. 30 South Puzhu Road, Nanjing 211816, People's Republic of China; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Wenyuan Road, Nanjing 210023, People's Republic of China. Electronic address: [email protected].

DOI: 10.1016/j.biotechadv.2019.107453

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MeSH Terms: Biosynthetic Pathways, Drug Industry, Fermentation, Vitamin K 2