Terpenoid bio-transformations and applications via cell/organ cultures: a systematic review.

Wafaa A Tawfik, Thomas Efferth, Paul W Paré, Mahmoud Sakr, Faiza M Hammouda, Abou El-Hamd H Mohamed, Hesham R El Saedi, Abdessamad Debbab, Alaa M Shahen, Mohamed-Elamir F Hegazy, Abdelaaty A Shahat, Khaled A Shams, Nahla S Abdel-Azim, Soleiman E Helaly, Taha A Hussien, Tarik A Mohamed, Abdelsamed I Elshamy

Journal: Critical reviews in biotechnology 2020;40(1):64-82

PMID: 31663377

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Abstract

Structurally diverse natural products are valued for their targeted biological activity. The challenge of working with such metabolites is their low natural abundance and complex structure, often with multiple stereocenters, precludes large-scale or unsophisticated chemical synthesis. Since select plants contain the enzymatic machinery necessary to produce specialized compounds, tissue cultures can be used to achieve key transformations for large-scale chemical and/or pharmaceutical applications. In this context, plant tissue-culture bio-transformations have demonstrated great promise in the preparation of pharmaceutical products. This review describes the capacity of cultured plant cells to transform terpenoid natural products and the specific application of such transformations over the past three decades (1988-2019).

Address: Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.; Department of Phytochemistry, National Research Centre, Giza, Egypt.; Department of Natural Compounds Chemistry, National Research Centre, Giza, Egypt.; Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-Cho, Tokushima, Japan.; Pharmacognosy Department, Faculty of Pharmacy, Deraya University, Minia, Egypt.; Department of Microbial Drugs, Helmholtz Centre for Infection Research, Braunschweig, Germany.; Department of Chemistry, Faculty of Science, Aswan University, Aswan, Egypt.; Debbab Med, Munich, Germany.; Division of Pharmacognosy, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.; Department of Chemistry, Faculty of Science, El-Menoufia University, Shebin El-Kom, Egypt.; Genetic Engineering and Biotech. Division, National Research Centre, Giza, Egypt.; Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX, USA.

DOI: 10.1080/07388551.2019.1681932

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MeSH Terms: Biotransformation, Cell Culture Techniques, Plant Structures, Plants, Terpenes