Preterm premature rupture of the membranes and antioxidants: the free radical connection.

Peter D Wall, Eva K Pressman, James R Woods

Journal: Journal of perinatal medicine 2003;30(6):447-57

PMID: 12530100

Abstract

AIM

To discuss the role of oxidant stress in preterm, premature rupture of the membranes (PPROM).

RESULTS

There is evidence to suggest that preterm, premature rupture of the membranes occurs secondary to focal collagen damage in the fetal membranes.

CONCLUSION

Oxidant stress caused by increased ROS formation and/or antioxidant depletion may disrupt collagen and cause premature membrane rupture. We propose that supplementation with vitamins C and E may synergistically protect the fetal membranes, and decrease the risks of PPROM.

Address: Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Rochester Medical Center, Rochester, New York, USA. [email protected]

DOI: 10.1515/JPM.2002.071

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MeSH Terms: Antioxidants, Dietary Supplements, Female, Fetal Membranes, Premature Rupture, Humans, Pregnancy, Vitamins