D Amino Acids Highlight the Catalytic Power of the Ribosome.

Jean Lehmann, Shixin Ye

Journal: Cell chemical biology 2020;26(12):1639-1641

PMID: 31680066

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Abstract

The possible mechanism(s) by which ribosomes make peptide bonds during protein synthesis have been explored for decades. Yet, there is no agreement on how the catalytic site, the peptidyl transferase center (PTC), promotes this reaction. Here, we discuss the results of recent investigations of translation with D amino acids that provide fresh insights into that longstanding question.

Address: Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, University of Paris-Sud, Campus Paris-Saclay, 91198 Gif-sur-Yvette, France. Electronic address: [email protected].; Sorbonne University, Institute of Biology Paris-Seine (IBPS), LCQB, CNRS, INSERM, 75005 Paris, France. Electronic address: [email protected].

DOI: 10.1016/j.chembiol.2019.10.007

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MeSH Terms: Amino Acids, Biocatalysis, Catalytic Domain, Peptidyl Transferases, Protein Biosynthesis, RNA, Transfer, RNA, Transfer, Amino Acyl, Ribosomes