Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues.

Jacob A Herring, Weston S Elison, Jeffery S Tessem

Journal: Cells 2020;8(11):1373

PMID: 31683815

Abstract

The Nr4a family of nuclear hormone receptors is composed of three members-Nr4a1/Nur77, Nr4a2/Nurr1 and Nr4a3/Nor1. While currently defined as ligandless, these transcription factors have been shown to regulate varied processes across a host of tissues. Of particular interest, the Nr4a family impinge, in a tissue dependent fashion, on cellular proliferation, apoptosis and fuel utilization. The regulation of these processes occurs through both nuclear and non-genomic pathways. The purpose of this review is to provide a balanced perspective of the tissue specific and Nr4a family member specific, effects on cellular proliferation, apoptosis and fuel utilization.

Address: Nutrition, Dietetics and Food Science Department, Brigham Young University, Provo, Utah 84602, USA. [email protected].; Microbiology and Molecular Biology Department, Brigham Young University, Provo, Utah 84602, USA. [email protected].; Nutrition, Dietetics and Food Science Department, Brigham Young University, Provo, Utah 84602, USA. [email protected].; Nutrition, Dietetics and Food Science Department, Brigham Young University, Provo, Utah 84602, USA. [email protected].

DOI: 10.3390/cells8111373

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MeSH Terms: Apoptosis, Cell Nucleus, Cell Proliferation, DNA-Binding Proteins, Energy Metabolism, Humans, Inflammation, Nerve Tissue Proteins, Nuclear Receptor Subfamily 4, Group A, Member 1, Nuclear Receptor Subfamily 4, Group A, Member 2, Organ Specificity, Orphan Nuclear Receptors, Receptors, Steroid, Receptors, Thyroid Hormone, Signal Transduction