The Functions and Therapeutic Potential of Heat Shock Proteins in Inflammatory Bowel Disease-An Update.

Abdullah Hoter, Hassan Y Naim

Journal: International journal of molecular sciences 2020;20(21):5331

PMID: 31717769

Abstract

Inflammatory bowel disease (IBD) is a multifactorial human intestinal disease that arises from numerous, yet incompletely defined, factors. Two main forms, Crohn's disease (CD) and ulcerative colitis (UC), lead to a chronic pathological form. Heat shock proteins (HSPs) are stress-responsive molecules involved in various pathophysiological processes. Several lines of evidence link the expression of HSPs to the development and prognosis of IBD. HSP90, HSP70 and HSP60 have been reported to contribute to IBD in different aspects. Moreover, induction and/or targeted inhibition of specific HSPs have been suggested to ameliorate the disease consequences. In the present review, we shed the light on the role of HSPs in IBD and their targeting to prevent further disease progression.

Address: Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.; Department of Physiological Chemistry, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.

DOI: 10.3390/ijms20215331

Link outs

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Medical:

https://medlineplus.gov/crohnsdisease.html

Miscellaneous:

https://assays.cancer.gov/CPTAC-391

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HSPD1-1

MeSH Terms: Chaperonin 60, Colitis, Ulcerative, Crohn Disease, Disease Progression, HSP70 Heat-Shock Proteins, HSP90 Heat-Shock Proteins, Heat-Shock Proteins, Heat-Shock Proteins, Small, Humans, Intestinal Neoplasms, Intestine, Large, Mitochondrial Proteins, Prognosis