Adrenocortical carcinoma: Impact of surgical treatment.

Eric Mirallié, Claire Blanchard, Cécile Caillard, Patrice Rodien, Claire Briet, Stéphanie Mucci, Delphine Drui, Antoine Hamy

Journal: Annales d'endocrinologie 2020;80(5-6):308-313

PMID: 31722787

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Abstract

Compared to benign adrenal lesions, secreting or otherwise, malignant adrenocortical carcinoma is rare. Overall prognosis is poor, with <50% 5-year survival. Various prognostic factors have been identified, some tumor-related and others directly linked to surgical treatment. Surgery is the only possible curative treatment, and is decided upon in a multidisciplinary medical-surgical team meeting. Surgical approach (laparotomy vs. laparoscopy) remains a matter of debate. In the light of a recent literature search, the present review reassesses the prognostic criteria of surgical resection, the quality of which determines overall and recurrence-free survival.

Address: Clinique de chirurgie digestive et endocrinienne, IMAD, Hôtel Dieu, CHU de Nantes, place Alexis-Ricordeau, 44093 Nantes cedex 01, France. Electronic address: [email protected].; Clinique de chirurgie digestive et endocrinienne, IMAD, Hôtel Dieu, CHU de Nantes, place Alexis-Ricordeau, 44093 Nantes cedex 01, France.; Service d'endocrinologie diabétologie et nutrition, CHU d'Angers, rue Larrey, 49933 Angers cedex 9, France.; Service de chirurgie viscérale et endocrinienne, CHU d'Angers, rue Larrey, 49933 Angers cedex 9, France.; Service d'endocrinologie et maladies métaboliques, l'institut du thorax, Hôpital Laennec, CHU de Nantes, 44093 Nantes cedex 01, France.

DOI: 10.1016/j.ando.2019.09.001

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MeSH Terms: Adrenal Cortex Neoplasms, Adrenocortical Carcinoma, Humans, Laparoscopy, Laparotomy, Lymph Node Excision, Lymphatic Metastasis, Margins of Excision, Neoplasm Recurrence, Local, Survival Rate, Treatment Outcome