GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.

Address: Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA.; Department of Pathology and Laboratory Medicine, University of California (UCLA), Los Angeles, Los Angeles, CA, 90095, USA.; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.; Institute of Cardiovascular Science, University College London, London, WC1 6BT, UK.; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA.; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 20892, USA.; Department of Genetic Epidemiology, University of Regensburg, Regensburg, 93053, Germany.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.; Institute of Health Informatics, University College London, London, WC1E 6BT, UK.; Icelandic Heart Association, Kopavogur, IS-201, Iceland.; University of Iceland, Reykjavik, 101, Iceland.; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, 8036, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, 8036, Austria.; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 3015, The Netherlands.; Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.; Institute for Medical Informatics, Statistics and Epidemiology, , University of Leipzig, Leipzig, 04107, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04107, Germany.; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, CHU Bordeaux, F-33000, Bordeaux, France.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20520, Finland.; Department of Genetics and Genomic Sciences, The Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Clinical Gene Networks AB, Stockholm, 104 62, Sweden.; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK.; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300, RC, The Netherlands.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Population Sciences Branch, Division of Intramural Research, NHLBI, NIH, Framingham, MA, 01702-5827, USA.; National Heart, Lung and Blood Institute's Intramural Research Program, Framingham Heart Study, Framingham, MA, 01702-5827, USA.; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39216, USA.; Department of Neurology, University Medicine Greifswald, Greifswald, 17475, Germany.; Department of Medicine, Columbia University, New York, NY, 10032, USA.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.; Department of Biochemistry, Maastricht Centre for Systems Biology (MaCSBio), CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, 6229, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, 17475, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, 25157, USA.; Menzies Health Institute Queensland, Griffith University, Southport, QLD, 4222, Australia.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, 3015, The Netherlands.; MRC Unit for Lifelong Health and Ageing at UCL, London, WC1E 6BT, UK.; Department of Medicine, University of Groningen, University Medical Center Groningen, Groningen, 2300, The Netherlands.; Department of Epidemiology, and School of Medicine, Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.; Department of Epidemiology and Public Health, University College London, London, WC1E 6BT, UK.; Clinical Gene Networks AB, Stockholm, 104 62, Sweden.; Department of Pathophysiology, Institute of Biomedicine and Translation Medicine, University of Tartu, Biomeedikum, Tartu, 51010, Estonia.; Department of Cardiac Surgery, Tartu University Hospital, Tartu, 51010, Estonia.; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, 17177, Sweden.; Department of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala, 75108, Sweden.; Department of Clinical Sciences in Malmö, Lund University, Malmö, SE-205 02, Sweden.; Department of Pathology and Laboratory Medicine, University of California (UCLA), Los Angeles, Los Angeles, CA, 90095, USA.; Department of Human Genetics, University of California (UCLA), Los Angeles, CA, 90095, USA.; Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, 1081, HL, The Netherlands.; Applied Sciences, Premier, Inc., Charlotte, NC, 28277, USA.; Department of Clinical Sciences in Malmö, Lund University, Malmö, SE-205 02, Sweden.; Department of Medicine, University of Verona, Verona, 37134, Italy.; Department of Medical Biotechnology and Translational Medicine, Università di Milano, Milan, 20133, Italy.; Centro Cardiologico Monzino, IRCCS, Milan, 20138, Italy.; St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA, 02135, USA.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04107, Germany.; Institute of Laboratory Medicine, University Hospital Munich, LMU Munich, 80539, Germany.; Centro Cardiologico Monzino, IRCCS, Milan, 20138, Italy.; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, 20133, Italy.; Department of Clinical and Experimental Medicine, Internal Medicine, Angiology and Arteriosclerosis Diseases, University of Perugia, Perugia, 06123, Italy.; Centro Diagnostico Italiano, Milan, 20147, Italy.; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, 77030-3411, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94309, USA.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, 75185, Sweden.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, G1120, USA.; Centro Cardiologico Monzino, IRCCS, Milan, 20138, Italy.; Heart Center Leipzig, Leipzig, 04103, Germany.; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, CHU Bordeaux, F-33000, Bordeaux, France.; Centre for Brain Research, Indian Institute of Science, Bangalore, 560012, India.; Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Department of Cardiology, Leiden University Medical Center, Leiden, 2300, RC, The Netherlands.; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, 6525, GA, The Netherlands.; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.; Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04107, Germany.; Institute for Laboratory Medicine, University of Leipzig, Leipzig, 04109, Germany.; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, 17177, Sweden.; Department of Biostatistics, University of Washington, Seattle, WA, 98105, USA.; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.; Department of Internal Medicine, Rush University Medical Center, Chicago, IL, 60612, USA.; Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, GA, 6525, The Netherlands.; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, 751 05, Sweden.; Department of Genetics, University of North Carolina, Chapel Hill, NC, 27516, USA.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, 17475, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Munich, 80539, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, 81377, Germany.; Department of Neurology, Center for Neurology and Neurosurgery, Johann Wolfgang Goethe-University, Frankfurt am Main, 60323, Germany.; Department of Epidemiology and Public Health, University College London, London, WC1E 6BT, UK.; Institute for Social and Economic Research, Essex University, Colchester, CO4 3SQ, UK.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.; Data Tecnica International, Glen Echo, MD, 20812, USA.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20520, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20521, Finland.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.; Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, 3012, Switzerland.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.; Electrocardiography Research Group, School of Medicine, Universidad Industrial de Santander, Bucaramanga, Santander, 680003, Colombia.; Department of Genetics and Genomic Sciences, The Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Mental Illness Research Education and Clinical Center (MIRECC), James J. Peters VA Medical Center, Bronx, New York, NY, 10468, USA.; Population Health Research Institute, St George's, University of London, London, SW17 0RE, UK.; Inserm U1167, F-59000, Lille, France.; Institut Pasteur de Lille, U1167, F-59000, Lille, France.; Université de Lille, U1167 - RID-AGE & Centre Hospitalier Universitaire de Lille, U1167, F-59000, Lille, France.; Sorbonne Université, Cardiovascular Prevention Unit, Pitié Salpétrière Hospital, Paris, 75013, France.; Collaborative Health Studies Coordinating Center, Department of Biostatistics, University of Washington, Seattle, WA, 98195, USA.; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Munich, 80539, Germany.; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, 70210, Finland.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04107, Germany.; Institute of Laboratory Medicine, University of Leipzig, Leipzig, 04109, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, 93053, Germany.; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, 8036, Austria.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333, The Netherlands.; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 1QU, UK.; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, 17177, Sweden.; Mental Health and Wellbeing, Institute of Health and Wellbeing, University of Glasgow, Glasgow, G12 0XH, UK.; Department of Primary Care & Population Health, University College London, London, WC1E 6BT, UK.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden.; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300, RC, The Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, 2300, RC, The Netherlands.; Department of Neurology, Boston University School of Medicine, Boston, MA, 02118, USA.; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, FI-70210, Finland.; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, 98101, USA.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, BS8 1QU, UK.; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, BS8 1TH, UK.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33014, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, 33014, Finland.; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, S-171 77, Sweden.; Department of Cardiology, Karolinska University Hospital, Stockholm, S-171 77, Sweden.; Genetics Institute, University College London, London, WC1E 6BT, UK.; Departments of Medicine and Epidemiology, Johns Hopkins University, Baltimore, MD, 21205, USA.; National Heart, Lung and Blood Institute's Intramural Research Program, Framingham Heart Study, Framingham, MA, 01702-5827, USA.; Section of Biomedical Genetics, School of Medicine, Boston University, Boston, MA, 02215, USA.; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.; Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.; Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, 8010, Austria.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.; Department of Epidemiology & Biostatistics, Imperial College London, London, SW7 2AZ, UK.; GGZ inGeest and Amsterdam Public Health Research Institute, Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, 1081 HV, The Netherlands.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, 98101, USA.; Cardiovascular Health Research Unit and Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, 98195, USA.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.; Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Centre for Clinical Brain Sciences, and UK Dementia Research Institute at the University of Edinburgh, Edinburgh, EH16 4SB, UK.; Swansea University Medical School, Swansea, SA2 8PP, UK.; Centre for Cardiovascular Genetics, Institute Cardiovascular Science, University College London, London, WC1E 6BT, UK.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17475, Germany.; Department of Genetics and Genomic Sciences, The Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. [email protected].; Clinical Gene Networks AB, Stockholm, 104 62, Sweden. [email protected].; Department of Pathophysiology, Institute of Biomedicine and Translation Medicine, University of Tartu, Biomeedikum, Tartu, 51010, Estonia. [email protected].; Integrated Cardio Metabolic Centre, Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, SE-141 57, Sweden. [email protected].; Intramural Administration Management Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, 20892, USA. [email protected].; Cardiology Section, Boston Veteran's Administration Healthcare, Boston, MA, 02130, USA. [email protected].; Harvard Medical School, Boston, MA, 02115, USA. [email protected].