Gastrointestinal Polyposis in Pediatric Patients.

Suzanne P MacFarland, Kristin Zelley, Bryson W Katona, Benjamin J Wilkins, Garrett M Brodeur, Petar Mamula

Journal: Journal of pediatric gastroenterology and nutrition 2020;69(3):273-280

PMID: 31211762

Abstract

Gastrointestinal polyps are mucosal overgrowths that, if unchecked, can undergo malignant transformation. Although relatively uncommon in the pediatric age group, they can be the harbingers of multiorgan cancer risk and require close management and follow-up. Additionally, as many polyposis syndromes are inherited, appropriate genetic testing and management of relatives is vital for the health of the entire family. In this review, we discuss both common and uncommon childhood gastrointestinal polyposis syndromes in terms of clinical presentation, management, and surveillance. We also detail any additional malignancy risk and surveillance required in the pediatric age group (<21 years old). Through this review, we provide a framework for gastroenterologists to manage the multifaceted nature of pediatric polyposis syndromes.

Address: Division of Oncology, Department of Pediatrics.; Division of Gastroenterology, Department of Medicine.; Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia.; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
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