Extracellular vesicles in vascular calcification.

Wenling Yang, Bu Zou, Yangfeng Hou, Wei Yan, Tao Chen, Shunlin Qu

Journal: Clinica chimica acta; international journal of clinical chemistry 2020;499():118-122

PMID: 31493375

Full Text on Elsevier Science View on PubMed

Abstract

Vascular calcification is associated with adverse cardiovascular events that increase the risk of cardiovascular death. Unfortunately, the pathogenesis of vascular calcification is complex and incompletely understood. As important intercellular signaling molecules, the role of extracellular vesicles (EVs) in vascular calcification has attracted wide attention in recent years. This review will briefly describe the role of EVs (mainly including exosomes and microvesicles) in the process of vascular wall calcification focusing on the specific mechanisms of smooth muscle cell (SMC) differentiation and calcium-phosphorus balance to illustrate the relationship between EVs and vascular calcification. It is likely that EVs may be prognostic markers in some cardiovascular diseases and have potential therapeutic potential.

Address: Pathophysiology Department, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, University of South China, Hengyang, Hunan 421001, PR China; Clinic Department, Hengyang Medical College, University of South China, Hengyang 421001, PR China.; Pathophysiology Department, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, University of South China, Hengyang, Hunan 421001, PR China. Electronic address: [email protected].

DOI: 10.1016/j.cca.2019.09.002

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MeSH Terms: Extracellular Vesicles, Humans, Muscle, Smooth, Vascular, Vascular Calcification