Jakub Treml, Veronika Leláková, Karel Šmejkal, Tereza Paulíčková, Šimon Labuda, Sebastian Granica, Jaroslav Havlík, Dagmar Jankovská, Tereza Padrtová, Jan Hošek
Journal: Biomolecules 2020;9(9):468
PMID: 31505897
The stilbenoids, a group of naturally occurring phenolic compounds, are found in a variety of plants, including some berries that are used as food or for medicinal purposes. They are known to be beneficial for human health as anti-inflammatory, chemopreventive, and antioxidative agents. We have investigated a group of 19 stilbenoid substances in vitro using a cellular model of THP-1 macrophage-like cells and pyocyanin-induced oxidative stress to evaluate their antioxidant or pro-oxidant properties. Then we have determined any effects that they might have on the expression of the enzymes catalase, glutathione peroxidase, and heme oxygenase-1, and their effects on the activation of Nrf2. The experimental results showed that these stilbenoids could affect the formation of reactive oxygen species in a cellular model, producing either an antioxidative or pro-oxidative effect, depending on the structure pinostilbene () worked as a pro-oxidant and also decreased expression of catalase in the cell culture. Piceatannol () had shown reactive oxygen species (ROS) scavenging activity, whereas isorhapontigenin () had a mild direct antioxidant effect and activated Nrf2-antioxidant response element (ARE) system and elevated expression of Nrf2 and catalase. Their effects shown on cells in vitro warrant their further study in vivo.
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