Retinoic acid metabolism.

P M Petkovich

Journal: Journal of the American Academy of Dermatology 2001;45(5):S136-42

PMID: 11606945

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Abstract

The tissue distribution of retinoic acid (RA) throughout development is highly restricted, defined by the expression patterns of enzymes involved in RA synthesis and catabolism. Presented is a summary of recent research that examines the role of some of the enzymes involved in RA distribution, particularly those involved in RA catabolism (P450RAI). These latter enzymes protect against premature exposure to RA, and the implications of these findings are discussed.

Address: Cancer Research Laboratories, Queen's University, Third Floor, Botterell Hall, Kingston, Ontario, Canada K7L 3N6. [email protected]

DOI: 10.1067/mjd.2001.113715

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MeSH Terms: Catalysis, Cytochrome P-450 Enzyme System, Humans, Keratolytic Agents, Mixed Function Oxygenases, Neoplasms, Retinoic Acid 4-Hydroxylase, Signal Transduction, Tretinoin, Vitamin A Deficiency