Interaction of isotretinoin with endogenous retinoids.

H Törmä

Journal: Journal of the American Academy of Dermatology 2001;45(5):S143-9

PMID: 11606946

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Abstract

Isotretinoin exhibits antiproliferative and antiandrogenic effects on the sebaceous glands by yet unknown mechanisms. This review focuses on a putative mechanism of action of isotretinoin involving the interaction of isotretinoin with the metabolism of endogenous retinoids and androgens.

Address: Department of Medical Sciences, Section of Dermatology and Venereology, University Hospital, SE-751 85 Uppsala, Sweden. [email protected]

DOI: 10.1067/mjd.2001.113716

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MeSH Terms: Acne Vulgaris, Androgens, Cell Division, Dermatologic Agents, Humans, Isotretinoin, Retinoids, Sebaceous Glands