NSE & S100B protein blood level assessment during a long-distance trail race.

Romain Jouffroy, Barbara Alves, Benoit Mauvieux, Luc Mallet, Jean-Louis Beaudeux, Charles-Henry Cottart

Journal: Annales de biologie clinique 2020;77(5):532-536

PMID: 31638583

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Abstract

UNLABELLED

The acute and chronic consequences of long-distance running on brain function have received little attention. The impact of such a hard-physical burden associated with sleep privation during such events such has never been explored in terms of neuropsychological function and brain damage.

METHODS

Blood samples were collected from 4 athletes before, during and at the end of one of two races: Grand Raid de la Réunion 2017 (GRR: 165 km, elevation gain: 9529 m, 2 runners) and Trail de la Bourbon 2017 (TB: 111 km, elevation gain: 6433 m, 2 runners). Serum S100B and NSE levels were measured for each runner before, during and after the race.

RESULTS

Serum S100B levels (normal range: < 0.15 μg/L) increased early during the race and remained high up to the end of the race in all 4 runners (range: 0.17-0.59 μg/L). NSE level (normal range: < 15 μg/L) increased in 3 of the 4 runners (range: 16.8-39.2 μg/L).

CONCLUSIONS

This preliminary study shows the potential interest of S100B and NSE serum assessment during long-distance races. Further studies are needed to confirm these results and to investigate the origins and significance of this increase in brain injury markers.

Address: Intensive care unit, Anaesthesiology, SAMU, Necker-Enfants malades Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France, Departments of anaesthesia, Clinical epidemiology and biostatistics, Michael De Groote school of medicine, Faculty of health sciences, McMaster University, Hamilton, Ontario, Canada, IRMES - Institute for research in medicine and epidemiology of sport, Paris, France.; Intensive care unit, Anaesthesiology, SAMU, Necker-Enfants malades Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.; UMR-S 1075-COMETE Mobilités : vieillissement, pathologie, santé, Pôle des formations et de recherche en santé (PFRS), Université de Caen Normandie, Inserm, Caen, France, Unité de chronobiologie, Fondation Rothschild, Paris, France.; Assistance Publique-Hôpitaux de Paris, Psychiatry department, Hôpitaux universitaires Henri Mondor - Albert Chenevier, Université Paris-Est, Créteil, France, Sorbonne Universités, UPMC Université Paris 06, CNRS, Inserm, Institut du cerveau et de la moelle épinière (ICM), Paris, France, Department of mental health and psychiatry, Global health institute, University of Geneva, Geneva, Switzerland.; Department of clinical chemistry, Necker-Enfants malades Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France, Université de Paris, Faculté de pharmacie, Paris, France.

DOI: 10.1684/abc.2019.1482

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MeSH Terms: Adult, Athletic Performance, Biomarkers, Female, Humans, Male, Mountaineering, Phosphopyruvate Hydratase, Physical Endurance, Preliminary Data, Reunion, Running, S100 Calcium Binding Protein beta Subunit, Time Factors