Recognizing phosphatidylinositol 3-phosphate.

S Misra, G J Miller, J H Hurley

Journal: Cell 2001;107(5):559-62

PMID: 11733055

Free Full Text on Elsevier Science View on PubMed

Abstract

Phosphatidylinositol 3-phosphate directs the endosomal localization of regulatory proteins by binding to FYVE and PX domains. New structures of these domains complexed with the phosphoinositide headgroup show how interactions with phosphate and hydroxyl groups differentiate this lipid from all others.

Address: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

DOI: 10.1016/s0092-8674(01)00594-3

Link outs

Free resources

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0092...

MeSH Terms: Endosomes, Models, Molecular, Molecular Structure, Phosphatidylinositol Phosphates, Protein Structure, Tertiary, Protein Transport, Signal Transduction, Zinc Fingers