Low-Renin Hypertension.

Shobana Athimulam, Natalia Lazik, Irina Bancos

Journal: Endocrinology and metabolism clinics of North America 2020;48(4):701-715

PMID: 31655771

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Abstract

Low-renin hypertension affects 30% of hypertensive patients. Primary hyperaldosteronism presents with low renin and aldosterone excess. Low-renin, low-aldosterone hypertension represents a wide spectrum of disorders that includes essential low-renin hypertension, hereditary forms of hypertension, and hypertension secondary to endogenous or exogenous factors. This review addresses the different conditions that present with low-renin hypertension, discussing an appropriate diagnostic approach and highlighting the genetic subtypes within familial forms.

Address: Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55905, USA.; Department of Internal Medicine, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55905, USA.; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55905, USA. Electronic address: [email protected].

DOI: 10.1016/j.ecl.2019.08.003

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MeSH Terms: Aldosterone, Citrus paradisi, Cushing Syndrome, Glycyrrhiza, Humans, Hyperaldosteronism, Hypertension, Liddle Syndrome, Metabolism, Inborn Errors, Renin