Hypoglycemia in cystic fibrosis: Prevalence, impact and treatment.

Amir Moheet, Christine L Chan, Andrea Granados, Katie Larson Ode, Antoinette Moran, Alberto Battezzati

Journal: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2020;18 Suppl 2():S19-S24

PMID: 31679723

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Abstract

Hypoglycemia is a common and feared complication of insulin therapy. As in type 1 and type 2 diabetes, people with cystic fibrosis related diabetes are also at risk for hypoglycemia related to insulin therapy. Spontaneous hypoglycemia is also common in patients with CF without diabetes, who are not on glucose lowering medications. Spontaneous hypoglycemia in CF may also occur during or after an oral glucose tolerance test. In this review, we will discuss the definition, epidemiology, pathophysiology and impact of hypoglycemia, with a focus on people with cystic fibrosis. We will also review strategies to manage and prevent hypoglycemia.

Address: Department of Medicine, University of Minnesota, Minneapolis, MN, USA. Electronic address: [email protected].; Children's Hospital Colorado, University of Colorado, Aurora, CO, USA.; Department of Pediatrics, Washington University School of Medicine in St. Louis, MO, USA.; Department of Pediatrics, University of Iowa Stead Family Children's Hospital, Iowa City, IA, USA.; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.; International Center for the Assessment of Nutritional Status (ICANS), Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli Studi di Milano, Milan, Italy.

DOI: 10.1016/j.jcf.2019.08.004

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MeSH Terms: Cystic Fibrosis, Humans, Hypoglycemia, Prevalence