Cystic fibrosis related diabetes: Nutrition and growth considerations.

Beth A Kaminski, Bracha K Goldsweig, Aniket Sidhaye, Scott M Blackman, Teresa Schindler, Antoinette Moran

Journal: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2020;18 Suppl 2():S32-S37

PMID: 31679727

Free Full Text on Elsevier Science View on PubMed

Abstract

Nutritional considerations are crucial to the optimal management of cystic fibrosis related diabetes (CFRD). The development of abnormal glucose tolerance and CFRD can have negative effects on CF nutritional status. Treatment of CFRD with insulin replacement is essential; however, medical nutrition therapy is important to maintain nutritional status while normalizing blood glucose levels. CF Foundation Nutritional Guidelines are recommended for the nutritional management of CFRD; specifically, the diet should be high in calories, protein, fat, and salt. Carbohydrate intake is not limited, but carbohydrate counting can be used to guide insulin dosing and maintain consistent blood glucose levels. CFTR modulator therapy shows early promise for the improvement of growth and nutritional parameters in CF.

Address: Department of Pediatrics, Division of Endocrinology, University Hospitals Rainbow Babies and Children's Hospital, 11100 Euclid Avenue, Cleveland, OH 44106, USA. Electronic address: [email protected].; Children's Hospital and Medical Center, 8200 Dodge Street, Omaha, NE 68114, USA. Electronic address: [email protected].; Division of Endocrinology, Diabetes and Metabolism, The Johns Hopkins University School of Medicine, 1830 E. Monument Street, Suite 333, Baltimore, MD 21287, USA. Electronic address: [email protected].; Division of Pediatric Endocrinology, The Johns Hopkins University School of Medicine, 200 N. Wolfe Street, Room 3120, Baltimore, MD 21287, USA. Electronic address: [email protected].; Department of Pediatrics, Division of Pulmonology, University Hospitals Rainbow Babies and Children's Hospital, 11100 Euclid Avenue, Cleveland, OH 44106, USA. Electronic address: [email protected].; Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, University of Minnesota, East Building, Room MB671, 2450 Riverside Avenue, Minneapolis, MN 55455, USA. Electronic address: [email protected].

DOI: 10.1016/j.jcf.2019.08.011

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MeSH Terms: Cystic Fibrosis, Diabetes Mellitus, Growth, Humans, Nutrition Therapy