Diagnostic and grading accuracy of F-FDOPA PET and PET/CT in patients with gliomas: a systematic review and meta-analysis.

Jiarui Xiao, Yizi Jin, Ji Nie, Fukun Chen, Xuelei Ma

Journal: BMC cancer 2019;19(1):767

PMID: 31382920

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Abstract

BACKGROUND

Positron emission tomography (PET) and PET/computed tomography (PET/CT) imaging with 3,4-dihydroxy-6-[F] fluoro-L-phenylalanine (F-FDOPA) has been used in the evaluation of gliomas. We performed a meta-analysis to obtain the diagnostic and grading accuracy of F-FDOPA PET and PET/CT in patients with gliomas.

METHODS

PubMed, Embase, Cochrane Library and Web of Science were searched through 13 May 2019. We included studies reporting the diagnostic performance of F-FDOPA PET or PET/CT in glioma patients. Pooled sensitivity, specificity, and area under the summary receiver operating characteristic (SROC) curve were calculated from eligible studies on a per-lesion basis.

RESULTS

Eventually, 19 studies were included. Across 13 studies (370 patients) for glioma diagnosis, the pooled sensitivity and specificity of F-FDOPA PET and PET/CT were 0.90 (95%CI: 0.86-0.93) and 0.75 (95%CI: 0.65-0.83). Across 7 studies (219 patients) for glioma grading, F-FDOPA PET and PET/CT showed a pooled sensitivity of 0.88 (95%CI: 0.81-0.93) and a pooled specificity of 0.73 (95%CI: 0.64-0.81).

CONCLUSIONS

F-FDOPA PET and PET/CT demonstrated good performance for diagnosing gliomas and differentiating high-grade gliomas (HGGs) from low-grade gliomas (LGGs). Further studies implementing standardized PET protocols and investigating the grading parameters are needed.

Address: Department of Biotherapy, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, No.37, Guoxue Alley, Chengdu, 610041, Sichuan, China.; Medical College, Soochow University, Suzhou, 215006, Jiangsu, China.; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan, China.; Department of Nuclear Medicine, Yunnan Cancer Hospital, the Third Affiliated Hospital of Kunming Medical University, Kunming, 650118, Yunnan, China. [email protected].; Department of Biotherapy, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, No.37, Guoxue Alley, Chengdu, 610041, Sichuan, China. [email protected].

DOI: 10.1186/s12885-019-5938-0

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MeSH Terms: Adolescent, Adult, Aged, Brain Neoplasms, Child, Data Accuracy, Female, Fluorine Radioisotopes, Formycins, Glioma, Humans, Male, Middle Aged, Neoplasm Grading, Neoplasm Recurrence, Local, Positron Emission Tomography Computed Tomography, Positron-Emission Tomography, Publication Bias, ROC Curve, Radiopharmaceuticals, Ribonucleotides, Sensitivity and Specificity, Young Adult