The PRT protein family.

S C Sinha, J L Smith

Journal: Current opinion in structural biology 2002;11(6):733-9

PMID: 11751055

Full Text on Elsevier Science View on PubMed

Abstract

Members of the homologous PRT family are catalytic and regulatory proteins involved in nucleotide synthesis and salvage. New crystal structures have revealed key elements of PRT protein function, as well as glimpses of how the fold has evolved to perform both catalytic and regulatory functions.

Address: Department of Biochemistry, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. [email protected]

DOI: 10.1016/s0959-440x(01)00274-3

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MeSH Terms: ATP Phosphoribosyltransferase, Amino Acid Motifs, Catalysis, Magnesium, Protein Binding, Protein Folding, Protein Structure, Quaternary, Ribose-Phosphate Pyrophosphokinase, Sequence Homology