Abstract
[{"label":"UNLABELLED","text":"It has been suggested that in doubtful cases of coeliac disease, a high CD3 T-cell receptor gamma delta (TCR\u03b3\u03b4) intraepithelial lymphocyte count increases the likelihood of coeliac disease."},{"label":"AIM","text":"To evaluate the diagnostic accuracy of both an isolated increase of TCR\u03b3\u03b4 cells and a coeliac lymphogram (increase of TCR\u03b3\u03b4 decrease of CD3 intraepithelial lymphocytes) evaluated by flow cytometry in the diagnosis of coeliac disease."},{"label":"METHODS","text":"The literature search was conducted in MEDLINE and EMBASE. The inclusion criteria were: an article that allows for the construction of a 2 \u00d7 2 table of true and false positive and true and false negative values. A diagnostic accuracy test meta-analysis was performed."},{"label":"RESULTS","text":"The search provided 49 relevant citations, of which 6 were selected for the analysis, which represented 519 patients and 440 controls. Coeliac lymphogram: The pooled S and Sp were 93% and 98%, without heterogeneity. The area under the SROC curve (AUC) was 0.98 (95% CI, 0.97-0.99). TCR\u03b3\u03b4: Pooled S and Sp were both 95%, with significant heterogeneity. The AUC was 0.97 (95% CI, 0.95-0.98). : Both TCR\u03b3\u03b4 count and coeliac lymphogram assessed by flow cytometry in duodenal mucosal samples are associated with a high level of diagnostic accuracy for and against coeliac disease."}]
Address:
Department of Gastroenterology, Hospital Universitari Mutua Terrassa, 08221 Terrassa (Barcelona), Spain.
[email protected].; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, 28029 Madrid, Spain.
[email protected].; Department of Gastroenterology, Hospital Universitari Mutua Terrassa, 08221 Terrassa (Barcelona), Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, 28029 Madrid, Spain.
