What is new in endothelial neoplasia?

David J Papke, Jason L Hornick

Journal: Virchows Archiv : an international journal of pathology 2020;476(1):17-28

PMID: 31463731

Abstract

The classification of vascular neoplasms continues to evolve as we accumulate more genetic and clinical data, particularly for rare tumor types. Because of tumor rarity, changes to classification schema, overlapping histologic features, and in some cases, lack of morphologic evidence of vasoformation, vascular neoplasms present a diagnostic challenge. Here, we discuss recent developments in our understanding of vascular tumors, with a detailed discussion of epithelioid hemangioma, tufted angioma, kaposiform hemangioendothelioma, composite hemangioendothelioma, pseudomyogenic hemangioendothelioma, epithelioid hemangioendothelioma, and angiosarcoma.

Address: Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, USA. [email protected].

DOI: 10.1007/s00428-019-02651-4

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https://dx.doi.org/10.1007/s00428-019-02651-4

MeSH Terms: Calcium-Binding Proteins, Hemangioendothelioma, Hemangioendothelioma, Epithelioid, Hemangioma, Hemangiosarcoma, Humans, Kasabach-Merritt Syndrome, Proto-Oncogene Proteins c-myc, Sarcoma, Kaposi, Skin Neoplasms, Trans-Activators, Transcriptional Coactivator with PDZ-Binding Motif Proteins, Vascular Neoplasms