Whole-Genome Sequencing of an Uncommon Cryptococcus neoformans MLST43 Genotype Isolated in Nigeria.

Nnaemeka Emmanuel Nnadi, Domenico Giosa, Grace Mebi Ayanbimpe, Enrico D'Alessandro, Riccardo Aiese Cigliano, Christian Uchechukwu Oheri, John Chinyereze Aguiyi, Ifeoma Bessie Enweani, Orazio Romeo

Journal: Mycopathologia 2020;184(5):555-557

PMID: 31473911

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Abstract

Cryptococcosis is a human infection caused mainly by two species of the Cryptococcus genus, Cryptococcus neoformans and Cryptococcus gattii, whose populations contain several phylogenetically related haploid (VN/VG-types) and hybrid genotypes. Here, we report the whole-genome sequencing of a Nigerian C. neoformans VNII, Mat-α, strain with a rare multilocus-sequence-type (MLST) genotype (ST43).

Address: Department of Microbiology, Plateau State University, Plateau State, P.M.B 2012, Bokkos, Nigeria.; Department of Clinical and Experimental Medicine, University Hospital of Messina, Messina, Italy.; Department of Medical Microbiology, University of Jos, Jos, Nigeria.; Department of Veterinary Sciences, University of Messina, Messina, Italy.; Sequentia-Biotech SL, Barcelona, Spain.; African Centre of Excellence in Phytomedicine Research and Development (ACEPRD), University of Jos, Jos, Nigeria.; Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria.; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres, 98166, Messina, Italy. [email protected].

DOI: 10.1007/s11046-019-00376-1

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https://doi.org/10.1007/s11046-019-00376-1

MeSH Terms: Cryptococcosis, Cryptococcus neoformans, Genome, Fungal, Genotype, Humans, Multilocus Sequence Typing, Mycological Typing Techniques, Nigeria, Whole Genome Sequencing