Endemic Kashin-Beck disease: A food-sourced osteoarthropathy.

Kewei Wang, Jun Yu, Hui Liu, Yunqi Liu, Ning Liu, Yanhong Cao, Xufeng Zhang, Dianjun Sun

Journal: Seminars in arthritis and rheumatism 2021;50(2):366-372

PMID: 31548049

Full Text on Elsevier Science View on PubMed

Abstract

OBJECTIVE

Kashin-Beck disease (KBD) is an endemic osteoarthropathy, which causes disability and heavy socioeconomic burdens. The preventive measures have been taken in the past few decades. However, recent KBD-epidemiological trend and comprehensive effect of its preventive measures need to be evaluated.

METHODS

By employing typical survey, cross-sectional survey, case-control study, intervention trial, and national surveillance, the present study summarizes comprehensive role of KBD-preventive measures.

RESULTS

The endemic KBD is distributed in a long and narrow area of the world. The latest epidemic began in the late 1950s and lasted until the end of 1980s. Epidemiology of the KBD was characterized by early-onset, gender equality, agricultural area, regional discrepancy, family aggregation, annual fluctuation, etc. Multivariate regression analysis suggested that etiology of the KBD was food-related factors such as fungal contamination of grains, selenium deficiency, imbalance of protein intake, etc. A series of intervention measures for KBD control had been implemented since 1990s, and involved more than 300 million residents. National incidences were 22.1% in 1990, 16.0% in 1995, 12.3% in 2000, 5.5% in 2005, 0.38% in 2010, and 0.18 in 2015, respectively. Although new patients were annually decreased, it still affected 22,567,600 inhabitants and there were 574,925 patients in 2016.

CONCLUSIONS

Etiology of the KBD is food-sourced. Its decreased incidence may attribute to an effective implementation of preventive measures. It is possible to eradicate KBD from the earth in the near future.

Address: Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, 157 Baojian Road, Harbin 150081, People's Republic of China; Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Harbin Medical University, Harbin, People's Republic of China; China and Russia Medical Research Center, Harbin Medical University, Harbin, People's Republic of China; Harbin Medical University, Harbin, People's Republic of China.; Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, 157 Baojian Road, Harbin 150081, People's Republic of China; Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Harbin Medical University, Harbin, People's Republic of China; China and Russia Medical Research Center, Harbin Medical University, Harbin, People's Republic of China; Harbin Medical University, Harbin, People's Republic of China. Electronic address: [email protected].

DOI: 10.1016/j.semarthrit.2019.07.014

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MeSH Terms: Case-Control Studies, Child, Cross-Sectional Studies, Epidemics, Female, Food, Humans, Incidence, Kashin-Beck Disease, Male, Population Surveillance